A Case of Methimazole-Induced Acute Hepatic Failure in A Patient With Chronic Hepatitis B Carrier
نویسندگان
چکیده
We report a case of methimazole-induced acute hepatic failure, which occurred 17 weeks after initiation of the drug in a 43-year-old man with hyperthyroidism and hepatitis B surface antigenemia. Postmortem needle autopsy of the liver revealed an established micronodular cirrhosis secondary to hepatitis B with moderate septal/portal inflammation, marked cholestasis and scattered acidophilic bodies. The serum hepatitis B surface antigen (HBsAg) was positive, but reactivation of hepatitis B was unlikely in view of the absence of a serum hepatitis B e antigen (HBeAg) and hepatitis B virus deoxyribonucleic acid (HBV-DNA) and negative stain for HBsAg and hepatitis B core antigen (HBcAg) in the liver tissue.
منابع مشابه
Orthotopic Liver Transplantation for Etanercept-Induced Acute Hepatic Failure; a case report
The occurrence of hepatotoxicity following etanercept (tumor necrosis factor-alpha antagonist) prescription, has been studied well. However, an acute hepatic failure leading to liver transplant as an adverse effect of this drug has not been reported in the literature. In this article, we are going to present a case of acute liver failure followed by liver transplantation, in a 32 years old man ...
متن کاملDengue causing fulminant hepatitis in a hepatitis B virus carrier.
Dengue is an acute febrile illness resulting from infection by a flavivirus transmitted by the Aedes mosquito. It is characterized by bleeding manifestations and a plasma leak syndrome. Hepatic involvement in the form of elevation in transaminases is common. However, acute hepatic failure is uncommon. It is not known how the presence of an underlying chronic hepatitis or liver disease affects t...
متن کاملصفات مشخصه حاملین آنتی ژن سطحی هپاتیت ب
Background : preventing of hepatitis B needs recognition of it's causative agent and specific characteristic. Hospital staffs get most rating for hepatitis B carrier. The important point in this disease is the great number of client without symptoms, Antigen hepatitis B chronic carriers and different way for transmission. Objective : To determine specific characteristic of carrier with the ...
متن کاملGlyphosate Poisoning with Acute Fulminant Hepatic Failure
Background: Glyphosate containing herbicides are widely used the world over. They are marketed as nontoxic to humans, but numerous studies have showed that these glyphosate-based herbicides (GlySH) can cause multiorgan damage.1 Recent reports of animal studies on rats have raised a doubt of liver damage after long term exposure to GlySH. Case Presentation: a young male had chronic exposure to G...
متن کاملExpression of serum sCD163 in patients with liver diseases and inflammatory disorders.
OBJECTIVE To investigate the diagnostic values of soluble cluster of differentiation 163 (sCD163) in patients with liver failure or various inflammations. METHODS Serum samples were collected from patients admitted to the First Affiliated Hospital, Zhejiang University from October 2013 to January 2015 for treatment of with liver diseases, including liver failure (n=38), hepatitis B virus (HBV...
متن کامل